One can use the default shortcuts in windows using keyboard to minimize the usage of Mouse....

1. Windows Key+1/2/3......: Will opens the application which pinned to task bar
 
2. Ctrl+Shift+Esc : You know the short cut to open the task manager i.e Alt+Ctrl+Del But it will not open the Task Manager directly. So just change the it from now onwards.



3. Windows key+E: Will opens the My Computer window.
4. Windows Key+Pause/Break: opens the System Properties
5. Windows Key+ Left arrow/Right arrow/Up arrow/Down arrow: will re-size  the window to left/right/Maximize/Restore respectively.
6. Windows Key+D: will minimizes all the active windows and displays the Desktop
7. Alt+D: This works in Browser window, to go to address bar



8. Ctrl+E: Courser will appear in the Browser's Search Bar



9.  Alt + Space + x / r / n / m: to maximize / restore / minimize/ move resp. the current active window
10.  Alt + Tab: To switch between active windows